Elected to upgrade to Windows Anniversary Edition yesterday, which uninstalled CCleaner Professional version 5.21.5700. Following a successful reinstall, I cleaned out the crap and cleaned the registry. Today, upon rebooting Windows, I received a belatedly MicroSoft notification telling me it removed CCleaner due to incompatibility issues. Oddly, my reinstall is still present, accessible, and functioning.
Following advice on page one of this discussion, I opened an administrative command prompt and ran the two recommenced commands. The first: dism.exe /online /cleanup-image /restorehealth reported “The restore operation completed successfully”; the second, sfc /scannow reported “Windows Resource Protection did not find any integrity violations”. Again, my reinstall is still present, accessible, and functioning.
My non-professional assessment is twofold:
1/ Microsoft protected the integrity of its update by uninstalling applications that could conceivably cause Windows 10 to become corrupted.
2/ CCleaner was and remains fully comparable with MicroSoft's operating system.