I was a Nod32 user for years, until malware Virut stroke my system infecting every .exe, .html, etc. in all my hard drives.
It took me 5 Windows reinstall to finally get rid of it and the help of Dr. Web Cure It and the Kaspersky online service.
Since then I adopted Kaspersky Internet Security as my anti-virus of trust.
No problems at all so far. Detections are always correct, low number of false positives, constant updates, etc.
The company turned out to be very user friendly too. You gotta love anything with the K logo on it.
Currently trying Kaspersky PURE.