I cannot use portable as I don't have a usb stick.
I ran defraggler in safe mode and it defragged without issue, although the drive map seems to be malfunctioning because it shows a lot of fragmented files, but the readout says there is zero. If this is going to be the only way to use defraggler I will not be using it anymore, because having to boot into safe mode every time I want to defrag (which is once a week) is just nuts.
I am pretty sure its not my computer, because my husband told me that defraggler does not work on his computer either. His computer just got a fresh copy of windows 7 pro 64 bit put on it and defraggler wont defrag his computer either. Windows defragger works fine on his computer.
And I did reboot after unticking the box to replace window defrag.
I will run a system file check and see if that comes up with anything. Edit: I ran the scan it came up with nothing. I figured it wouldn't as this harddrive is less then a year old.