27/9/2015 Using windows 10 build 10547, got the same problem, but it is intermittent. Will try sticking with the 32 bit version.
After installing Microsoft Enhanced Mitigation Experience Toolkit and adding defraggler.exe and df.exe to EMET's application list, Defraggler crashed every time it attempted to analyse a disc. Even with all the mitigations turned off it still crashed. To get defraggler to work I deleted defraggler.exe ad df.exe from the application list.