I already solved my problem, just create new USER and, to save all my settings, copied my folder AppData from old user to new user. And now I use new Profile to work with comp, old one did not work correctly.
The problem was - I started Defraggler - in a middle of defragging process all my prog-links (exe, ini, etc) become as a PDF files.
I restart my comp - all my progs include autoruns, antivirus and all startup progs - didn't work. + All functions that starts from "control panel" gust start me PDF reader.
I didn't fined dissition, that why I created new user, now I use NEW Profile (new user).
And I delete Defraggler.