Sorry follks for thinking that Piriform had something to do with that...
I found out that my power supply is failing, my 5 volt is about 4.5, so the usb disk did not have enough juice to start anymore
Thanks to Alan_B idea, tried it on a second computer, disk worked fine so i added a transformer for my external disk and it's fine now.
To answer hazelnut, i ran speccy to do the inventory of my pc contents because i had to calculate the power supply needs for my new Asus p9x79 pc
Asus calculator told me that i needed at least 900W with the number of drives i actually have and my actual power supply is only 450W.
Thanks to all for your help