Hmmm, perhaps I wasn't clear enough.
My wife hasn't used the actual PDA for 6+ months, but she uses the Palm Desktop application to enter contact information, calendar events, etc. -- not to sync, but just as a PIM.
So, today when she launched Palm Desktop (a desktop application running under Win XP on her laptop), the contact data didn't appear.
Is it possible that ccleaner simply nuked some saved information from this app which resided in the registry?