I have the same issue. I use ACDSee Pro 2.5 and a bunch of image extensions are shown as unregistered by CCleaner registry integrity search. I open an image with ACDSee, it shows that this bunch of extensions are not registered with ACDSee and it re-registers them. I use CCleaner, it start saying that are unregistered extensions and so on.
And no, puting that folder or executable at excludes doesn't solve the problem, because it excludes from deleting the temp files, not from the registry changes done by that program.
