i tend to speed up my pc w/ an array of programs, one of which PC Pitstop Optimize (the unregistered version gives you the registry locations and recomended values, so you can do it manually)
i noticed that CCleaner misses a few articles that pitstop finds, some of which are;
ProgID entry: HKCR\VisualStudio.Launcher.sln
tons of TypeLib entries and Interface entries
and some performance+internet tweaks could be incorporated which are shown by the prog.
--edit--
i just noticed they releaced a new version that hides their fixes, i use v1.5.12.2 if you can dig it up somewhere it helps