I appreciate the advice but if merely to be cautious of program installations that require a reboot then I believe that option is superfluous.
IMHO it's better if there is a warning about "program installations that require a reboot" instead when you click on Analyze or Run Cleaner.
I understand that if you uncheck this option it will delete all files in C:\Windows\Temp\ regardless of age, saving you a bit of extra space by cleaning out those folders.
However, what is the disadvantage of having this option unchecked?