SpeechRuntime reappear after Registry clean
It looks like a placebo pseudo-solution. The registry key is still there, now CC doesn't show it to you.
From CC:
Problem | Data | Registry Key
ActiveX/COM Issue | LocalServer32\C:\Windows\SysWOW64\Speech_OneCore\Common\SpeechRuntime.exe -ToastNotifier | HKCR\CLSID\{265b1075-d22b-41eb-bc97-87568f3e6dab}
The Registry Key is a short for
Computer\HKEY_CLASSES_ROOT\CLSID\{265b1075-d22b-41eb-bc97-87568f3e6dab}
If you look for it you'll find it for sure. We are still
SpeechRuntime.exe -ToastNotifier is a new registry entry related to Windows 10 21H1.
It's also now used by certain components of Win 10 20H1 and 20H2.
Windows has put it on your computer because it is needed, and if you remove it then Windows will put it straight back.
Right click on it and 'Add to exclude list' then CCleaner will ignore it.
PS. We recommend that you don't regularly use the Registry Cleaner with Windows 10 or 11. Windows 10 and 11 changes the registry often w