CCleaner doing something to my Word, Excel, and PowerPoint software two days in a row. had to do OfficeSetup.exe both days to get them to open again.
Are you using the registry section? CCleaner free or pro?
Take a look at this post:
<a href="<___base_url___>/topic/64110-cant-open-microsoft-programs-after-running-ccleaner/#comment-340399" rel="">https://community.ccleaner.com/topic/64110-cant-open-microsoft-programs-after-running-ccleaner/#comment-340399</a>
(And check in CCleaner under "Performance Optimizer" if the Office applications are also in sleep state. If so, wake them all up again.)