It would be great if CCleaner also deletes the unnecessary ZIP files in the update folder of Spybot. After the update process they are not needed anymore.
And all the unnecessary backups of the windows hosts file. Every time you immunize your system Spybot adds a new backup file. I think keeping the latest one is enough.
Tested the first suggestion, worked fine and didn't get any problems with SpyBot (didn't have to download those again etc). In the meantime this could be added to Winapp2.ini-file.