Firstly,
You are running an ‘Insider Preview’ version of Windows 10, and on the ‘Fast Ring’ at that.
It’s important to remember that these are beta testing versions of Windows, and as such may be unstable and incompatible with existing software.
You are in effect doing unpaid testing for Microsoft before they release the market version.
No software can be guaranteed to run correctly with a beta version of Windows, the programme developers have never had a chance to see what Microsoft has changed.
Secondly,
All current, informed, advice is that registry cleaners should not be used on a regular basis.
They are a tool meant for emergency action on an infected/broken system, not for everyday usage.
They are not a maintenance tool.
They don’t speed up your system, and can possibly break a healthy system. (Which is not a great problem if it is already broken anyway).
This is especially the case with Windows 10.
Windows 10 is different to older Windows versions, it is evolving all the time, small changes every month, bigger changes every six months or so.
Edge in particular is changing rapidly. (Because they released it well before it was finished).
A lot of the changes are made in, or show up in, the registry.
Again Microsoft don’t inform the writers of registry cleaners about these changes, and so the cleaner can’t recognise them and can remove the wrong things.
So the advice is - Don't use a registry cleaner unless your system is infected/broken, especially not on Windows 10, and definitely not on an Insider Preview.