Question regarding Defraggler

I did a Full Defrag on my computer. When I click File List, I get a bunch of files. Should I check them all and press Defrag Checked or leave them alone? Please tell me the pros and cons of doing that, thanks!

EDIT: I checked all the files and click Defrag Checked. I got a popup saying: "Defrag Aborted. Some files were not defragmented. This operation cannot be done."

That is how I normally do my defrags

.

Click on the File list tab, hit Analyse, sort the Fragments column by descending size, select the first filename then scroll down and shift+select the first filename with 10 frags, then hit Defrag.

I then repeat for the Size column, selecting all files greater than 10,000KB.

That way I do a quick defrag of all files > 10 frags and all files > 10megs. What's left behind I can live with.

Even doing that, I will sometimes get "defrag aborted", it's usually due to files that are open eg: Outlook.

If you get that a lot, a DF from Safe Mode will fix it.

Selecting all the files in the list would just be like hitting Defrag on the first tab.