This is sort of a follow up to Ishi's thread here: http://forum.piriform.com/index.php?showtopic=32374&st=0 . Good thread, Ishi, helped me learn something new. Might be that everybody already knew this stuff, but it was new to me.
Just got Mint 10 installed onto a usb stick using LinuxLive USB Creator (LiLi), available HERE. Universal USB Installer didn't work for me, nor did installing from the DVD.
There is a good set of instructions for LiLi starting HERE
LiLi offers the option to make the usb persistent, and if you do you still have the option to boot it as persistent or live (no changes) each time.
You also have the option to run Mint in VirtualBox. You just plug the usb stick into a running windows box and click on "Virtualize_This_Key.exe", and you boot to Mint (or whatever distro you installed) in VirtualBox. Instructions are HERE.
You can install VirtualBox after you have the usb stick working. It's a zip file, you just unzip it into the usb stick.
It worked OK but the screen was a bit cramped. Still it is a nice feature.
Both LiLi and the VirtualBox installer make some changes to your registry.
Edit: Just edited this post from Mint in the virtual box under Powershadow without having to log out of windows.
One more interesting twist. You can save a "snapshot" of your working Mint setup by simply saving the file called casper-rw to another folder somewhere. Then if you mess something up you can delete casper-rw from the USB stick, copy the saved casper-rw back, and shazam !! you have the old setup back. It takes a while, the file is large, 2 gb here, but it is simple and it worked twice here.