Im new

Just downloaded CCleaner to clean up my windows 10 PC, in the Custom Clean section I can check or uncheck cookies, if i check to remove cookies will I lose my passwords to different websites I use?

Yes you will, go to options > cookies to keep and move the ones you want to keep to the right hand column

Remember that those ticks/unticks only apply to Custom Clean. (Health Check ignores them and does its own thing.

If it is staying logged into websites in the browser that you want, then the section to untick is 'Session' for the browser.

Cleaning the browser 'Session' logs you out of websites that you were logged into in that browser, and closes any tabs that you had open, so that the browser resarts in it's default state with only one tab open.

Some sites do still use cookies to store logins, so if you find that unticking Session isn't stopping those from being logged out then you have to start moving their cookies into 'Cookies to Keep'.

(Note: Don't tick 'Saved Passwords' whatever you do - Unless you actually want to clear out all the passwords that have been saved by/to your browser).