How to use registry cleaner

Can anyone give me any suggestions on how to use the issue cleaner on ccleaner. What boxes on the left should i make sure i have checked, or keeped unchecked to stay safe. Or what techniques should i use to make sure i am not deleting something important when i do use the registry cleaner. I already keep backups so theres no need to warn me about that.

If you mean the issues scan then the only real thing you should do is make a back up. Just clean everything it finds.

I have gotten where I dont even make back ups with ccleaner. I trust it fully.

Now for the cleaner, I would have all boxes checked except under the advanced part.