I have tried a number of different cleaner applications and by far CCleaner is my favourite!
One thing though... Can one exclude an application and if so how?
I use CCleaner regularly. Helps keep things moving nicely. However, when I do, the next time I use MSN Live Messenger I have to reset all the pictures and profiles. I have a simililar problem with F-Secure, which is "free" to me, through a rebranding agreement with F-Secure and my ISP. If I don't manually go down the list of "issues" and unselect "F-Secure" then I'll have to reinstall the software which can take quite a long time since the download in hundreds of MiBs.