Error opening file for writing

I get this error every time I update to a new version and I have just renewed my subscription and I get the same error. Clicking Abort and retry give the same error. If I ignore the installation continues. Can someone advise on how to sort it our. TIA.

5cc638f2e83de_ErrorCC.JPG.a0af507dc1a7e791a59a1e59e1d231d4.JPG

See here

https://forum.piriform.com/topic/5739-solution-when-ccleaner-wont-install-or-download-windows/

I have this same problem, only the error is pointing to E:\

That's really strange because I don't have an E drive!

What the heck is going on here?