I am unsure what problems you mean. Can you not copy the old user files to the new profile?
Sometimes you must right-click a folder/properties/security tab/edit button/full control & ok to fix security permissions so that you can navigate again.
Malware causes this sometimes, as does corrupted profiles. It is likely your profile is corrupt, & hence the reason it is acting so strange.
rundll32.exe should only come up when Windows does not recognize what to open files with.
I presume that you do NOT do registry cleaning with CCleaner, & especially NOT with unused file extensions checkmarked?
This can kill a system dead if the wrong entries are removed, which is why I always never use that part of it.
rundll32.exe usually only comes up in 3 cases.
1) Malware/Viruses changed settings
2) User deleted/caused critical parts to go missing or messed up
3) Power spike or surge/failing hardware causes problems in Windows, causing it to lose settings that fail to save because of sudden hard restarts.
In all of those cases, the settings Windows uses to tell what to run a program with go awry.
You may be able to restore some functionality using a .reg/.cmd/.vbs./.bat file that you can find on the web.
Usually if you cannot launch EXE, you have to use another file type such as listed above, to restore it back so that you can function normally.
I am assuming that it was not just your .PDF extension that went awry on the old profile.