If the mouse hovers over the RUN button (bottom right) while it is grey, i.e.before CCleaner has initialized, it causes the program to crash. This is repeatable - happens every time. It typically takes about 2 - 3 seconds to initialiaze, so crashing the program is not difficult to do.
Win7 Pro running on Acer Travelmate with i5 processor 4GB RAM. 2Mb/s ADSL line
If you wait for the grey button to become blue, then CCleaner runs normally.
I too have an Acer Travelmate with a Core I5 and Win7 Pro, but I have never experienced this issue with CCleaner. Note that I rarely use my laptop's built-in touchpad (keep it disabled nearly all the time) and instead use a USB mouse. So I am guessing that either your laptop's touchpad driver or video driver may need to be updated? Do you see anything in the Event Viewer which might indicate the cause of CCleaner's crashes? Anyway, I never get device drivers for video, networking, or touchpads from Microsoft's Windows Update. Instead I always get these device drivers either directly from the computer vendor's web site or from the OEM manufacturer's web site since there may be non Microsoft certified device drivers available which fix specific issues such as this.