So... I ran CCleaner like I always do, did a Cleanup like I always do and... After restarting the computer because of an update for my avast! Antivirus, I found most of my programs stopped working.
Turns out CCleaner wiped my C:\ProgramData folder, and screwed up everything.
Now what?
Edit: So, MS Office 2016 no longer works, my Windows user picture shows a black square, had to reinsert my Malwarebytes AM key, had to reinsert my Start10 key, Bluestacks App Player is gone... This is just what I just found out broke.
Edit2: Tried to recover the folder with Recuva but most of the files are corrupted... Thanks CCleaner, I'll never use you again.