RGguard - SiteAdvisor competitor, add a toolbar that advises you about dangerous executables on websites.
RunScanner - Promising auto-starts listing tool. Version 1.0 just released.
MANDIANT Red Curtain - Interesting tool that tries to determine heuristically, how dangerous a file is based "on entropy (in other words, randomness), indications of packing, compiler and packing signatures, the presence of digital signatures, and other characteristics to generate a threat 'score'". For advanced users.
ThreatFire (beta) - Renamed CyberHawk. This security HIPS program detects malware based on behavior. This new beta, includes fully configurable advanced custom rules (formerly only for paid version) for the free version.
BE CAREFUL, MOST OF THE ENTRIES IN THIS THREAD ARE BETA. USE AT YOUR OWN RISK!
Thanks for the list. While these arent typically my kind of programs I plan to try a few of them(I hated cyberhawk and mcafee is just garbage). I'll give a few of the others a go once they are out of beta.
This post just reminded me that I've been running "RunScanner" since early September, and it's an ok application.
Runs from a simple exe file, and has a couple of useful features which include a Hosts File Editor as well as the usual process explorer/killer, startup etc..
Includes a link to a list of specialist forums as well as its home site to obtain info on any and all processes running.