Windows 7x64 (W7x64) maintains on C: a set of files used most frequently, and which therefore require the fastest access. You can see them on C: if you have Folder Options > Show hidden files turned ON. This file set is called the Prefetch Queue. It changes over time, is locked down by W7, and occupies the disk sectors which provide fastest access.
I am unable to find, via Google, any use of "Prefetch Queue" on the Piriform > Defraggler webpages. Therefore, the following question ...
What does Defraggler do to the W7 Prefetch Queue files? Anything, via appropriate settings selection? Nothing, because W7 locks these files?
Please clarify the interactions, if any, between Defraggler and W7's Prefetch Queue management. If there are optimum Defraggler settings for prefetch queues, please tell us what they are.