I've never seen CCleaner remove something from the drivers section of the registry. Perhaps going into Device Manager and using it's options such as installing drivers, etc., can get your USB3 to working again - but before doing that I'd recommend searching the Microsoft.com site and/or the computer manufacturer site for an easy automatted fix.
I actually did stick to the question, I (as a moderator) mentioned the unsupported OS because any further testing needs to take place in one that is supported as you did in post #6.
I discovered that WUDFRd is serviced in the Computer Management/Services.
I went at last into services.msc and opened alot of them before I found that in : Windows Driver Foundation - User-mode Driver Framework, the startup type was set to "manual".
I changed the startup type to “Automatic”, restarted, and plugged a dongel into USB3 and i worked !
It will now show up as “Automatic(trigger start)”
So I looked into it out my other computers. They are all set to "manual" and USB3 works fine.
Why is a puzzel - may be due to lack of some CPU instructions, is’t a small 17W CPU ? Or ?
The Ccleaner is free of charge - it must be other causes to this matter.
To the makers of Ccleaner : It should be implemented in Windows to clean out the crap MS i leaving behind in it’s own SW and other crap from installing 3.parts programs. Hope they buy you out for some billions
I’ve used Ccleaner for as long as it has existed, and never experienced that is has deleted usefull inventories anywhere on my computers. Not even when I enteret the Window 8 preliminarys - and now, same expirience with Windows 10. I also have some old programs - I presume not longer approved.
It has been a pleasure using it.
Due to several warnings given in this fora by users, or what for me appears to be official representals, I this time went for their idea that it this time could be true.
Advice : Don’t cry Wolf - the Ccleaner is safe to use.
Instead of going for the least possibility - go for what realy could be the case.
And : I'm not, like many others, the best to make my case clearly. Try to see throu that.