This may have already been asked before but I did try some due diligence first and can't seem to find the actual question. Is there any chance to uninstall or even delete any of the old version of CCleaner piling up on my HD?
Ccleaner should install over itself so I have to agree with hazelnut in assuming you mean the installers. Please do your best to clarify what you mean, thank you and welcomen
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Within my Downloads directory or file, I have ccsetup409 to ccsetup542. I would like to delete all except ccsetup542. Is this safe to do?
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Yes you can delete them. You can even throw away the latest after you've installed it.