Uninstall Problem

What the best way to get rid of some obsolete apps for which the installation source is no longer available -- making it impossible to uninstall them? These programs are totally unneeded and no longer unusable -- and I'd like to get rid of some of this junk, but I can't. Would it be a total disaster to simply delete the program folder(s)? I've even tried unlocker -- but that does nothing.

Have you tried safe mode Tom?

unlocker ain't working ? . yeah try Safe Mode .. and after that .. remove all entries from [Run > regedit]

Have you tried safe mode Tom?

Haven't tried Safe Mode -- I'll give it a shot.