Although I have only done this with CCleaner,
I am absolutely confident that if you follow my directions,
AND IF as a result you see what you hoped for when you attempted
"When I try to select PGPWDE01 to exclude it (Exclude->Add->Open)"
Then you will have achieved the exclusion setting that you were hoping for.
Regardless of how you achieve an exclusion,
I know nothing about the certainty of any such setting in defraggler because I have not experimented with them.
I was only offering assistance on how to achieve a setting.
I suggest that rather than worry about the consequences of damage to PGPWDE01 etc by utilities such as Defraggler (amongst many other tools),
it would be better to have a backup strategy that will restore normality regardless of whether damage was done by any utility or malware or a lightening strike down the chimney.
I have total confidence in Macrium Reflect to backup and restore all my partitions,
including the hidden and letter-less "System Reserved" partition that holds BitLocker and Boot files.
There are other competing partition image backups which also have users that live by them ( and die with them
)
N.B.
On two occasions this last year a Windows Security Update devastated my system and made it unusable.
Each time I rebooted and it failed, and then I inserted my Macrium Boot Recovery CD and it took only 6 minutes to restore my system back with the previous day's backup.
On one occasion my Laptop 30 GB HDD was replaced with an empty 160 GB HDD (a Christmas present)
and several minutes later the recovery CD had restored the image backups of the 30 GB drive,
and everything worked the same as the day before - but better because I had an extra 130 GB of unallocated space to use.