I think there should be no problem.
CCleaner Analyze shows two Temp files (sizes 2 KB and 4 KB) to zap
I selected the 4 KB one for exclusion
I closed CCleaner and edited the consequent CCleaner.ini
It concluded with the line
Exclude2=FILE|C:\Users\Alan\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content.IE5\6DP5YV6Z\|views[1]
I changed this to clean the same thing in any other profile by using an environmental variable
Exclude2=FILE|%LOCALAPPDATA%\Microsoft\Windows\Temporary Internet Files\Content.IE5\6DP?YV6Z\|vi?ws[1]
I launched CCleaner and Analyse only saw the small 2 KB file, it did not want to hit the 4 KB file even though :-
The path was defined with a standard environmental variable ;
The path included a wild card ;
The target was specified with a wild card.
I closed CC
I edited the INI to
Exclude2=FILE|%LOCALAPPDATA%\Microsoft\Windows\Temporary Internet Files\Content.IE5\6DP?YV6Z\|vi?ws[2]
I launched CC and Analyze saw that [2] did not match the exclusion - it was not excluded from being zapped
MY CONCLUSION :-
CCleaner will NOT allow you to type anything like %TEMP% within its GUI,
BUT REGARDLESS, what it can Analyse it can add that specific path to CCleaner.ini for your specific profile,
and you can edit the INI to replace your specific path with %TEMP% and it will exclude the file you have selected.from any other profile.
If you have a "standard install" the registry is used instead of a friendly INI,
in which case you must first use Options => Advanced => Save settings to INI.
Please note that when I use %TEMP% etc to Include stuff for deletion,
Analyze never shows %TEMP% but translates that to whatever is the current profile.
It is quite possible that should you change Options => Advanced => Save settings to INI. to use the registry,
then the registry will be given your specific path and not the general purpose %TEMP% route
However that probably does not matter,
the other users and profiles will know nothing of your changes because separate settings are kept in each user's registry.
If you want other profiles to get the same benefit you either stick with this "Save settings to INI",
or you have to perform all the above work whilst running CC in each profile, one at a time.