I've always thought iTunes was the best program you can use if you have an iPod, as it does what it does really well.
But it's always pissed me off big time that it has to be so damned big. I decided tonight to find out why, and I got the surprise of my life.
My iTunes folder, after updating to the latest version today stood at over 89mb, and it took all of 30 seconds to find out why it's so big, and how to chop it down to just over 27mb.
Go into these 3 folders in iTunes "Program Files" folder and strip out nothing else but useless language folders.
Make sure you just remove language folders, ".lproj" which you don't need, leaving 1 folder and any other files. Make sure you don't remove the other files.
The Quicktime Program Files folder also contains a lot of the same unnecessary ".lproj" language folders. Removing these took about 25mb off Quicktime. Not a lot, but added to the iTunes rubbish it's a good saving.
I'm sure iTunes now launches quicker, but that may be my imagination, but I've been running it all night, and removing these files has no effect at all on its function.
Of course, if you do this, take your time, and you can always reinstall it if you mess up.