I assume your other post was just the same thing? It was the same image but there was no text with it.
When an option is greyed out like that it generally means that it cannot reach the server that it need to check with.
If you look yours is telling you that in the box.
'Security' is the Software Updater, so for some reason yours is not reaching the server needed to check if there are any new versions of installed softwares.
It may just be an issue at the server in which case try again later, but it may also be your Antivirus or Firewall settings that are blocking your access to that server.
I see that you have McAfee so I'd check if it is that that is blocking the required connection.
<a href="https://www.mcafee.com/support/?articleId=TS100813&page=shell&shell=article-view" ipsnoembed="true" rel="external nofollow">https://www.mcafee.com/support/?articleId=TS100813&page=shell&shell=article-view</a>
PS if your Malwarbytes is the paid version running in real time then have you set the required exceptions in both MB4 and McAfee so that they can run happily together?
<a href="https://support.malwarebytes.com/hc/en-us/articles/360038522974-Malwarebytes-for-Windows-v4-antivirus-exclusions-list" ipsnoembed="true" rel="external nofollow">https://support.malwarebytes.com/hc/en-us/articles/360038522974-Malwarebytes-for-Windows-v4-antivirus-exclusions-list</a>
I notice that you also have a "PC Optimiser"of some description, I don't recognise the icon, it might be worth checking that for any blocking as well.