I updated myself to the V 2.0.0.5011.
I'm using it just the same as I used the previous version. No Virtual Partition, and set up to use RAM.
Ha! A paradox of the virtual world.
I have read where people use Sandboxie with Returnil protection turned on. That's tight security.
I'm almost sure Humpty's tried that with no problems, but I'd get that confirmed one way or the other first.