can you provide a screenshot of the list of registry entries you would clean, that's probably going to help the Devs pinpoint the culprit.
but on that front, why are you cleaning the registry so often, or at all?
there simply is no need and especially with the constant Win10 updates to the system, you are relying on Piriform to reflect any of those system changes into CC.
I've split this into its own unique topic since the other topic about the bug associated with Font Cache was something different.
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Win10 is an ever changing moving target with all the updates/upgrades it receives therefore in my opinion cleaning the registry will possibly only cause issues.