What happen when ccleaner starts? just not open or closes? Have you tried uninstalling then reinstalling ccleaner?
Are you saying you have located the temp file (69gb) but it wont let you delete it? If you have not found the large file download http://windirstat.info/download.php
Thanks for all your help. I did manage to delete the file. Strange though. It took me 4 or 5 reboots and I could finally get cclener to work and access the large file that was located in my root C:\ directory. Thanks again all.