open with application issue

What is an "open with application issue" in the registry cleaner? I have on my computer the application EXE file and use this program. If I clean the registry item as suggested, will the program still run without problems?

The Cleaner suggests that the issue is due to some program previosly removed. But that doesn't seem to be the case for my program. I have many of these type entries.

Those are just the programs that show up when you right click a file and go to open with. Example is if you right click a file and say open with and winamp but you uninstalled winamp so that entry is no longer needed. You can remove these entries with causing any problems. If you worried you can always just make a back up when you use the issues scanner.