The best way I can explain this is via these instructions - I did say it was particular in excluding some things.
What I had to do a long time ago was have all the settings stored in ccleaner.ini instead of the registry, it's much easier to edit the settings with Notepad when they're all in the INI:
1. Open CCleaner.
2. Go into 'Options > Advanced' and click 'Save all settings to INI file'
After having CCleaner 'Save all settings to INI file':
1. Re-input your Exclusion again, then close CCleaner.
2. Open the ccleaner.ini file located in the folder where CCleaner is installed.
3. At the end of your exclude file/path paste this at the very end of it: \|*.*
4. Save the INI file.
For whatever reason and I don't know why that upperslash | (if that's what it's called) is needed!
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So this whole folder path you've been trying to exclude won't get excluded because the upperslash | is missing:
C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\*.*
It needs to become this:
C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\|*.*
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You're also trying to exclude a single file which also won't work because the upperslash | is missing:
C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\MyExcelFile.xlsx.LNK
It needs to become this:
C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\|MyExcelFile.xlsx.LNK
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Note that I don't know how CCleaner will treat a "Recent" folder, and don't know if it will honor the exclude even if it's inputted correctly. You may still need to untick Office 2010 so that CCleaner won't clean any of it.
I would be nice if Piriform would finally eliminate the need for the upperslash!
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Edit:
Examples of how this would look in ccleaner.ini (you could just copy+paste this and then edit the username part by inputting your actual username -- and do note the excludes are numbered like Exclude1, Exclude2, etc.):
Exclude1=PATH|C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\|*.*
Exclude2=FILE|C:\Users\<Username>\AppData\Roaming\Microsoft\Office\Recent\|MyExcelFile.xlsx.LNK