Multiple user cleanup

I am currently looking to use CCleaner on a pc that has a large number of user profiles. These profiles have to be manually cleaned up from time to time to fix diskspace issues. I am might map every profile staticly one at a time. This will take a lot of administration to maintain this list of profiles and seperate files to clean up in each profile. Does anyone know a way to map every user profile at once. I have tried useing * and %username% but * does not work and %username% still only works with the current profile. Please come up with a way to either edit the *.ini file or add it to the gui of CCleaner. If you do send me an email. Thank you.