If you are using MS Edge Chromium, the release of Build 89 is quite a change. One new feature that conflicts with CCleaner is the Settings>System>Startup Boost feature. If this is on, CCleaner cannot automatically clean MS Edge Chromium because MS Edge is running all the time.
The vertical tab addition is kind of nice; however, will take some getting use to. ?
Microsoft has temporarily disabled the Edge Startup Boost by default and if you're now setting up a new computer or reinstalling Windows, the feature will not be present on the latest version of Edge.