When I restart my system having run CCleaner my McAfee suite advises that I am not fully protected and have to click the McAfee " Fix " button to reestablish full protection. This does not occur if I do not run CCleaner. Any help would be appreciated.
hitbit
You may want to look in your User Profile Temp folder for any McAfee resident files, often anti-malware programs will have some temporary files in there and removing them can cause severe issues with the software.
If you find McAfee related files or folders, you can then exclude them in CCleaner by clicking:
Options->Exclude
Anyone using Avast Antivirus, AVG Antivirus, etc., I'd recommend doing the same.
Make sure you have checked "Only delete files in Windows Temp folders older than 48 hours" in Settings > Advanced.