I run CCleaner with XP SP2 and IE7 - it's always been fine. I updated CC about a week ago and now everytime I run "Issues" it shows both .386 and .vxd. I resolve these and run Issues again straightaway but .386 and .vxd are there again.
The only other recent change to my PC is that I have run Regseeker recently.
Do I need to worry? How can I resolve these 2 issues permanently.
I hope you knew what you were doing with Regseeker and didn't just fix everything it found though or else it will almost certainly have caused some damage. Its a very powerful tool and the entries it finds should be treated with great caution (ie most entries it finds are not invalid).