Is there anything I need to add to ini file if C: isn't my OS partition?

I never thought of posting this topic until I read a post in another thread that stated Ccleaner looks at the C: drive for the installation.

I know it cleans my Firefox and IE browser files and they're on a different partition (I have to manually add the cache directory for Opera).

Is there anything I need to do to the ini file for an OS install that's not on the C: partition?