Andavari, is this the Desktop Maestro from PC Tools? What do you specifically like about that app?
It's from PC Tools. There really isn't a whole lot of difference from RegMech other than it cleans up junk files and that's about it.
Andavari, have you tried System TuneUp ?
For me (on Vista 64 bit), it is the only other app I need together with CCleaner.
The reg clean function is also very careful and does not show unsafe entries. Also the app gives you complete freedom to delete\not delete what you want!