http://img209.imageshack.us/img209/5019/ccleaner9kr.png
See that image, you see, I'm getting about 250 in total of problems EVERY SINGLE TIME i run the program..
I'm not sure how to remove it..
How often are you running it? What happens when you click "Fix Selected Issues"? If you fix them, then scan again, are they back?
About every.. 2-3 days, once I fix selected, it just deletes, and then next time i restart, same thing.
I checked a random sample of those extensions in your screenshot. They appear to be QuickTime downloads, games, etc. Are you downloading music or playing games on the internet?
If so, cleaning them is pointless ... the file types will be re-registered each time.
It does look like some Quicktime extensions, and/or another media player more notably Winamp as I noticed "HKCR\.NSV". Also I don't understand why "HKCR\.Folder" would be listed as that's a part of Window unless on your system it's missing the PersistentHandler sub-key.
Certain keys will return when you launch their application, for instance if Winamp or any other media player is set to re-associate filetypes at startup there'd be the cause of it (perhaps), but it doesn't make too much sense that they'd be considered invalid by the Issues scanner if the host app is installed.