How do you run CCleaner on a D:\ partition or network drive?

Hi there

Firstly, thanks for such a great piece of software. I was hoping that you would be able to help me with this query.

I have a network drive that I backup each night to partition D: on my desktop computer. This seems to contain a lot of temporary files and I was wondering how I can use CCleaner to remove these and any other unnecessary files?

Can you tell me what to please?

Many Thanks