2006 should have been called "The Year of the 0-day Threat."
0-day threats are security problems involving brand new exploits. Typically these include new virus threats or exploits of previously unknown flaws in computer products.
I know you're a great advocate for SandBoxie Humpty. I'm planning to give it a try in the new year. I hope you don't have any objections to me sending you the occasional PM asking for advice?