Fix selected issues - How safe?

Before hitting the 'Fix selected issues...' button I thought I'd just ask, how safe is it? Maybe it's a daft question but I'd just like to know the 'risk' before cleaning the registry. Are there any issues which could cause problems if 'fixed'? I guess I can make a reg backup and go for it but I would be interested in the views and experiences of others first.

Thanks in advance.

Rooster

Highly and very remotely unlikely that CCleaner will mess up the registry. It's the safest cleaning tool available!

Thanks for the feedback Andavari.