CCleaner includes my Malwarebytes and Windows Defender among Utilities for cleaning, but it ignores my ESET NOD32. Unfortunately NOD32 acquires about 50 MB per day of backup files which should be removed by any cleanup program. They are obvious for their .dat.bak extension. Old EasyCleaner found them. With CCleaner you can add a "custom" file: C:\ProgramData\ESET\ESET NOD32 Antivirus\backup\*.dat.bak so they're removed.
It would be nice if CCleaner expanded its database of popular applications, since CCleaner should be better than us at finding where the applications keep unnecessary files.