I've seen Win10 systems act weird after cleaning everything listed as invalid in the registry section of CCleaner - although you really shouldn't be doing that especially without a good backup in place, and I'm not referring to the .REG backup that CCleaner will create I'm referring to a full registry backup such as with System Restore. When the weirdness happens it usually takes several reboots for it to sometimes self-correct some things, and in other instances it requires an automatic update be applied to correct others before it starts acting more-or-less normal again.
Being that Win10 is still relatively new cleaning it's registry in my opinion is something to completely avoid - unless of course it's some specific Microsoft Fixit that is downloaded from Microsoft or from the PC manufacturer to fix a known particular issue.