Delete useless files in registry

Today as i was in the middle of editing some things in my registry i detected some files of programs that no longer exist in my system.

I use CCleaner of course.I also like Registry Cleaner Expert so i use it too although it's not free.

i wonder is it safe to delete everything that doesn't exist in my system?Is there any good guide with some more information about registry issues?

If those entries points directly to programs that you don't got anymore, then it's safe to delete. If you are unsure, you can always make a backup of that entry (right click>Export).

Yes, registry cleaners are unable to find all invalid entries from your registry. I have also deleted many entries manually. You bumped to them from time to time...

Thanks for the quick reply mate , i have deleted manually a lot of stuff .